Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction
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چکیده
منابع مشابه
Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction
BACKGROUND Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure. Consequently, new therapeutic targets are urgently required to achieve this aim. Expression of the Ru...
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Myocardial infarction (MI) is accompanied by inflammatory responses that lead to the recruitment of leukocytes and subsequent myocardial damage, healing, and scar formation. Because monocyte chemoattractant protein-1 (MCP-1) (also known as CCL2) regulates monocytic inflammatory responses, we investigated the effect of cardiac MCP-1 overexpression on left ventricular (LV) dysfunction and remodel...
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Over the last decade there has been growing interest in “bedside” protein and cellular markers of inflammation and adverse outcome after acute myocardial infarction (AMI) (1–16). In this issue of the Journal, Maekawa et al. (17) address the prognostic significance of peripheral monocytosis found at two to three days after reperfused AMI as a cellular marker for clinical outcome and its possible...
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For over 2 millennia, physicians have strived to relieve pain, heal, and cause no harm. However, we depend on therapeutic drugs that have side effects and unknown pleiotropic effects. A host of publications and media coverage over the last 2 years alerted us to cardiovascular (CV) risks associated with chronic use of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and selective cyclo...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0243483